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Introduction: Protein phosphorylation and signal transduction in bacteria
Author(s) -
Saier Milton H.
Publication year - 1993
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240510102
Subject(s) - signal transduction , pep group translocation , phosphatase , phosphorylation , protein kinase a , response regulator , protein phosphorylation , microbiology and biotechnology , kinase , biology , regulator , biochemistry , phosphoenolpyruvate carboxykinase , chemistry , enzyme , bacterial protein , gene
A single type of reversible protein‐phosphorylating system, the ATP‐dependent protein kinase/phosphatase system, is employed in signal transduction in eukaryotes. By contrast, recent work has revealed that three types of protein‐phosphorylating systems mediate signal transduction in bacteria. These systems are (1) classical protein kinase/phosphatase systems, (2) sensor‐kinase/response‐regulator systems, and (3) the multifaceted phosphoenolpyruvate‐dependent phosphotransferase system. Physiological, structural, and mechanistic aspects of these three evolutionarily distinct systems are discussed in the papers of this written symposium. © 1993 Wiley‐Liss, Inc.