Premium
Altered RB expression is a prognostic clinical marker involved in human bladder tumorigensis
Author(s) -
Benedict Willian F.
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240501314
Subject(s) - retinoblastoma , suppressor , bladder cancer , gene , tumor suppressor gene , biology , cancer research , tumor progression , cancer , genetics , carcinogenesis
We are now beginning to understand the development of bladder cancer at the molecular level. Tumor evolution involves the interaction of both oncogense and tumor suppressor gene. One of the key tumor suppressor genes in this process is the retinoblastoma (RB) gene. Much has been learned recetnly about the role of this gene in the tumor progression and prognosis of bladder cancer, although several questions are still unaswererd. The progress made on this subject in our laboratory as well as others will be the focus of this report. © 1992 Wiley‐Liss, Inc.