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The lobund‐wistar rat model of prostate cancer
Author(s) -
Pollard Morris
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240501220
Subject(s) - prostate cancer , cancer , prostate , cancer research , medicine , biology
Two models of preventable metastasizing autochthonous prostate adenocarcinoma (PA) have been described in Lobund‐Wistar (L‐W) rats: spontaneous PAs that develop at a mean age of 26 months: and induced PAs that develop at a mean time of 10.5 months. Both are similar in many respects to the counterpart disease in man. PAs develop spontaneously, and by induction through a combination of N ‐methyl‐ N ‐nitrosourea (MNU)/testosterone treatments. Our investigations with L‐W rats show that PA is manifested spontaneously in 26% of aged of aged L‐W rats, and by induction in approximately 90% of younger rats. It is characterized by metastatic adenocarcinoma initiated in, and expanding from, the dorso‐lateral and anterior lobes, and occasionally in the seminal vesicles. It is regulated by genetic, hormonal, and age‐related mechanisms. Spontaneous PAs are prevented by life‐long moderate (25%) diet restriction and, in rats at risk of developing induced PA, by early treatments with estradiol, with dihydrotestosterone, with a retinoid, and by castration. While the “premalignant” stages of induced tumorigenesis are susceptible to intervention, the overtly malignant stage resists therapeutic trails with the same agents and procedures. The transition from dependency to autonomy has not yet been defined. © 1992 Wiley‐Liss, Inc.