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Transforming growth factors and related peptides in gastrointestinal neoplasia
Author(s) -
Coffey Robert J.,
McCutchen Carol M.,
GravesDeal Ramona,
Polk William H.
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240501120
Subject(s) - transforming growth factor , receptor , biology , phenotype , transgene , genetically modified mouse , cell growth , cancer research , microbiology and biotechnology , gene , endocrinology , genetics
Transforming growth factor α and β 1 (TGFα and TGFα 1 ) are representative members of two distinct and expanding families of polypeptide grwoth factors TGFα is an epithelial cell mitogen, whereas TGFβ 1 inhibits epithelial cell growth; the role of these factors in contributing to the transofrmed phenotype is uncertain. Steady state mRNA expression for these growth factors and their receptors in a panel of human colon cancers and adjacent normal mucosa is presented. Based in part on results from transgenic mice in which TGFα is selectively overproduced in the mammary gland, a possible role for TGFα as a tumor promoter in the process of transformation is discussed. © 1992 Wiley‐Liss, Inc.