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HMG‐Like chromosomal proteins in Trypanosoma cruzi
Author(s) -
Morales Mónica,
Galanti Norbel,
Oñate Eddie,
Imschenetzky Maria
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240500308
Subject(s) - hmg coa reductase , biology , trypanosoma cruzi , microbiology and biotechnology , high mobility group , biochemistry , gene , enzyme , reductase , parasite hosting , world wide web , computer science
Abstract HMG‐like chromosomal proteins from Truypansoma cruzi were studies. Four HMG‐like proteins, designated HMG A, HMGA‐B, HMG‐C, and HMG‐E, were isolated and found to have molecular weights of 35.5 kd, 27.5 kd, 21.8 kd and 10.4 kd, respectively. Immunological relatedness was demonstrated between the mammalian HMG 1,2 and the HMG‐A and HMG‐B from T. cruzi . The relative amount of HMG‐C and HMG‐E proteins vary in T. cruzi depending to the proliferative stage of the cells. HMG‐E protein is increased in proliferating cells when compared to its level in non‐proliferating cells. HMG‐C is increased in the non‐proliferating cells. Probably, the shifts observed in the relative amount of HMG‐like proteins are related to the proliferating cells of this flagellate. The results are consistent with those described for other lower eukaryotes where the HMG‐like proteins isolated are similar but not identical to HMG proteins from vertebrates. © 1992 Wiley‐Liss, Inc.