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Cytokine triggered molecular pathways that control cell cycle arrest
Author(s) -
Kimchi Adi
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240500102
Subject(s) - cytokine , biology , microbiology and biotechnology , cell growth , signal transduction , function (biology) , gene , cell cycle checkpoint , cell cycle , genetics
Recent progress has been made concerning the understanding of the molecular pathways that mediate the growth suppressive effects of inhibitory cytokines. Interferons, interleukin‐6 and transforming growth factor‐β were investigated in these studies. Cell lines that display growth sensitivity to all three cytokines and growth resistant derivates provided a suitable genetic background to determine whether common or unique post‐receptor elments mediate the effects of each cytokine. three nuclear genes, c‐ myc , RB, and cyclin A were found to be common key downstream targets along the cytokine induced growth suppressive pathways. Genetic and pharmacological manipulations proved that these molecular responses fall into few complementary pathways that function in parallel to achieve the cytokine mediated GO/G1 arrest. New strategies, such as knock out anti‐sense gene cloning were developed and they currently provied powerful tools for the isolation of genes along the signaling pathways of growth arrest. © 1992 Wiley‐Liss, Inc.