Premium
Teratocarcinoma F9 cells induced to differentiate with sodium butyrate produce both tissue‐type and urokinase‐type plasminogen activators
Author(s) -
Takeda Masashi,
Kosaka Mitsuko,
Nishina Yukio,
Sawada Ken,
Matsumoto Keishi,
Nishimune Yoshitake
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240490311
Subject(s) - plasminogen activator , teratocarcinoma , urokinase , retinoic acid , sodium butyrate , cell type , chemistry , butyrate , cell , microbiology and biotechnology , cell culture , cellular differentiation , biology , biochemistry , endocrinology , gene , genetics , fermentation
Sodium butyrate (NaB) can induce teratocarcinoma cell differentiation as retinoic acid (RA). However, the function of these two agents seems to be a little different [Kosaka et al., Exp Cell Res, 192 : 46–51, 1991]. F9 cells treated with NaB synthesize both tissue‐type (tPA) and urokinase‐type (uPA) plasminogen activator, though RA induces only tPA production. Urokinase‐type PA is demonstrated to exist in association with membrane and to localize its activity to the close environment of the cell surface. This may cause the specific cell morphology and characteristics of differentiated F9 cells induced with NaB.