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Role of vitamin D in bone resorption
Author(s) -
Suda Tatsuo,
Takahashi Naoyuki,
Abe Etsuko
Publication year - 1992
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240490110
Subject(s) - osteoclast , bone resorption , chemistry , microbiology and biotechnology , stromal cell , progenitor cell , cellular differentiation , vitamin d and neurology , monocyte , osteoblast , medicine , endocrinology , immunology , stem cell , biology , biochemistry , in vitro , gene
The idea that vitamin D must function at the bone site to promote bone mineralization has long existed since its discovery as an anti‐rachitic agent. However, the definite evidence for this is still lacking. In contrast, much evidence has accumulated that 1α,25(OH) 2 D 3 is involved in bone resorption. 1α,25(OH) 2 D 3 tightly regulates differentiation of osteoclast progenitors into osteoclasts. Osteoclast progenitors have been thought to belong to the monocyte‐macrophage lineage. 1α,25(OH) 2 D 3 greatly stimulates differentiation and activation of mononuclear phagocytes. Recent reports have indicated that differentiation of mononuclear phagocytes into osteoclasts is strictly regulated by osteoblastic cells, the process of which is also stimulated by 1α,25(OH) 2 D 3 . In the differentiation of mononuclear phagocytes into osteoclasts, the target cells for 1α,25(OH) 2 D 3 appear to be osteoblastic stromal cells. Osteoblastic cells produce several proteins such as BGP, MGP, osteopontin and the third component of complement (C3) in response to the vitamin. They appear to be somehow involved in osteoclast differentiation and functions. Thus, 1α,25(OH) 2 D 3 seems to be involved in the differentiation of osteoclast progenitors into osteoclasts directly and also by an indirect mechanism involving osteoblastic cells. The precise role of osteoblastic cells in osteoclast development has to be elucidated in the future.