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Vascular permeability factor: A unique regulator of blood vessel function
Author(s) -
Connolly Daniel T.
Publication year - 1991
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240470306
Subject(s) - angiogenesis , microbiology and biotechnology , vascular endothelial growth factor b , regulator , endothelial stem cell , vascular permeability , vascular endothelial growth factor , vascular endothelial growth factor c , vascular endothelial growth factor a , endothelium , chemistry , vascular endothelial growth inhibitor , biology , endocrinology , cancer research , biochemistry , vegf receptors , in vitro , gene
Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent polypeptide regulator of blood vessel function. VPF promotes an array of responses in endothelium, including hyperpermeability, endothelial cell growth, angiogenesis, and enhanced glucose transport. VPF regulates the expression of tissue factor and the glucose transporter. All of the endothelial cell responses to VPF are evidently mediated by high affinity cell surface receptors. Thus, endothelial cells have a unique and specific spectrum of responses to VPF. Since each of the responses of endothelial cells to VPF are also elicited by agonists, such as bFGF, TNF, histamine and others, it remains a major challenge to determine how post‐receptor signalling pathways maintain both specificity and redundancy in cellular responses to various agonists.