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Transcriptional regulation of basic fibroblast growth factor gene expression in capillary endothelial cells
Author(s) -
Weich Herbert A.,
Iberg Niggi,
Klagsbrun Michael,
Folkman Judah
Publication year - 1991
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240470209
Subject(s) - basic fibroblast growth factor , autocrine signalling , fibroblast growth factor , angiogenesis , microbiology and biotechnology , fibroblast growth factor receptor 2 , growth factor , fibroblast growth factor receptor 3 , biology , paracrine signalling , fibroblast , fgf1 , fibroblast growth factor receptor 4 , endothelial stem cell , chemistry , fibroblast growth factor receptor , in vitro , cell culture , cancer research , biochemistry , receptor , genetics
The growth of capillary endothelial cells (BCE) is an important regulatory step in the formation of capillary blood vessels. In vivo, the proliferation of these cells is stringently controlled. In vitro they can be stimulated by polypeptide growth factors, such as acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF). Since bFGF is synthesized and stored by vascular endothelial cells, this mitogen may play an important role in an autocrine growth regulation during angiogenesis. Here, evidence is presented for induction of the mRNA of bFGF by bFGF itself. A similar increase of bFGF mRNA was observed in response to thrombin and after treatment with phorbol ester. These results suggest that an autocrine loop may exist that may serve to modulate the mitogenic response in BCE under various physiological conditions, (e.g., wound healing and new capillary formation).