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DNA and RNA within the nucleus: How much sequence‐specific spatial organization?
Author(s) -
Carter Kenneth C.,
Lawrence Jeanne Bentley
Publication year - 1991
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240470205
Subject(s) - compartmentalization (fire protection) , nucleic acid , rna , dna , computational biology , sequence (biology) , spatial organization , biology , nucleus , genetics , microbiology and biotechnology , evolutionary biology , biochemistry , gene , enzyme
Spatial organization of various nuclear components is often proposed as means by which nuclei more efficiently carry out their various tasks. Such functional compartmentalization may involve a sequence‐specific packaging and placement of DNA and RNA. Here we review recent insights, allowed primarily by advances in fluorescent in situ hybridization methodology, into the organization of nucleic acids within individual nuclei.