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Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations
Author(s) -
Prockop Darwin J.,
Oh Joo Youn
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.24046
Subject(s) - mesenchymal stem cell , progenitor cell , in vivo , stem cell , stromal cell , biology , microbiology and biotechnology , medicine , bioinformatics , neuroscience , cancer research , genetics
Abstract There is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs. J. Cell. Biochem. 113: 1460–1469, 2012. © 2011 Wiley Periodicals, Inc.