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Biocompatible controlled release polymers for delivery of polypeptides and growth factors
Author(s) -
Langer Robert,
Moses Marsha
Publication year - 1991
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240450406
Subject(s) - controlled release , biocompatible material , chemistry , biomolecule , epidermal growth factor , growth factor , delivery system , polymer , fibroblast growth factor , biophysics , nanotechnology , biochemistry , materials science , biomedical engineering , pharmacology , biology , organic chemistry , engineering , receptor
Abstract The development of biocompatible, controlled release systems for macromolecules has provided the opportunity for researchers and clinicians to target and deliver, on site, biologically active factors. This advance has also facilitated the purification and characterization of a number of important biomolecules. These systems include controlled release delivery systems which release proteins through porous polymer matrices, degradable polymeric delivery systems, and modulated polymer release systems. These areas of research will be reviewed with regards to their design, release kinetics, and biocompatibilities. The utilization of these systems to release such biologically important polypeptides as growth factors (e.g., fibroblast growth factor, epidermal growth factor, transforming growth factor‐B) as well as a number of important inhibitory factors (e.g., nitrosoureas, angiogenesis inhibitors) in both in vivo and in vitro studies will be discussed.