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Hepatoma‐associated nuclear matrix nonhistone antigens
Author(s) -
Kilianska Zofia,
Krajewska Wanda M.,
Xie Ronglin,
KlyszejkoStefanowicz Leokadia,
Chiu JenFu
Publication year - 1991
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240450313
Subject(s) - hamster , polyclonal antibodies , antigen , non histone protein , matrix (chemical analysis) , nuclear matrix , nuclear protein , biology , microbiology and biotechnology , chemistry , biochemistry , histone , chromatin , immunology , dna , gene , chromatography , transcription factor
Polyclonal antibodies generated against a group of high molecular weight nonhistone proteins from Morris hepatoma 7777 were used in immunological studies of hepatoma‐associated nonhistone proteins in rat and hamster. We revealed the presence of cross‐reactive antigens in rat Morris hepatomas 7777 and 8994, and in hamster Kirkman‐Robbins hepatoma, but not in normal rat or hamster livers. These specific nonhistone proteins were found to be preferentially localized in the nuclear matrix of rat Morris hepatoma 7777 as well as hamster Kirkman‐Robbins hepatoma.