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Developmental changes in expression of a tumor‐associated protein in the rat fetus
Author(s) -
Runge Steven W.,
Larroya Saroj,
Schumm Dorothy E.,
Webb Thomas E.
Publication year - 1989
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240410304
Subject(s) - fetus , cytosol , biology , fetal protein , gestation , monoclonal antibody , messenger rna , binding protein , antibody , rna , protein expression , andrology , microbiology and biotechnology , medicine , endocrinology , biochemistry , immunology , pregnancy , gene , genetics , enzyme
Monoclonal antibodies specific for a rat tumor‐associated protein cross‐react with a similar protein present in the cytosol of the rat fetus. The oncofetal protein exists as two species of approximate molecular weight 50 and 55 kDa which promote the transport of RNA from isolated nuclei. During rat fetal development, the protein first increases in concentration from approximately 12 to 16 days gestation and then drops to non‐detectable levels perinatally.