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Myc family of cellular oncogenes
Author(s) -
DePinho Ronald,
Mitsock Lisa,
Hatton Kimi,
Ferrier Pierre,
Zimmerman Kathy,
Legouy Edith,
Tesfaye Abeba,
Collum Robert,
Yancopoulos George,
Nisen Perry,
Kriz Ronald,
Alt Frederick
Publication year - 1987
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240330404
Subject(s) - microbiology and biotechnology , biology , computational biology , cancer research
The myc family of cellular oncogenes contains three well‐defined members: c‐myc, N‐myc and L‐myc. Additional structural and functional evidence now suggests that other myc‐family oncogenes exist. The overall structure and organization of the c‐, N‐. and L‐myc genes and transcripts are very similar. Each gene contains three exons: encoding a long 5′ untranslated leader and a long 3′ untranslated region. The proteins encoded by these myc genes share several stretches of significant homology. The conservation of sequences at the carboxy‐terminus of the L‐myc protein suggests that it is also a DNA‐binding, nuclear‐associated protein. Each myc gene will cooperate with an activated Ha‐ras oncogene to cause transformation of primary rat embryo fibroblasts. Characteristics of several new myc‐family members are described.