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Role of glandular kallikreins as growth factor processing enzymes: Structural and evolutionary considerations
Author(s) -
Isackson Paul J.,
Dunbar Joan C.,
Bradshaw Ralph A.
Publication year - 1987
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240330107
Subject(s) - kallikrein , biology , enzyme , evolutionary biology , biochemistry
Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association with mature forms of some hormones. However, limited distribution and low copy number in some species cast doubt on this hypothesis, and they may well play other physiological functions that remain to be elucidated.