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Viral therapy: Prospects for protease inhibitors
Author(s) -
Korant Bruce D.,
Towatari Takae,
Ivanoff Lucy,
Pettewa Steven Y.,
Brzin Joze,
Lenarcic Brigita,
Turk Vito
Publication year - 1986
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240320202
Subject(s) - protease , virology , cystatin , biology , virus , viral replication , poliovirus , cysteine protease , cystatin c , enzyme , biochemistry , renal function
Antiviral activities of known protease inhibitors were assayed in virus‐infected cell cultures. Some members of the cystatin superfamily, in particular chicken cystatin, were able to block virus replication. In a binding assay, using purified components, chicken and human cystatin were able to bind poliovirus protease with affinities which were reflected in their relative anitviral potencies. Prospects for application of protease inhibitors in clinical viral infections are discussed.