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Assembly and dynamics of the actin filament system in nonmuscle cells
Author(s) -
Pollard Thomas D.
Publication year - 1986
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240310202
Subject(s) - protein filament , actin , microbiology and biotechnology , dynamics (music) , biophysics , chemistry , physics , biology , biochemistry , acoustics
Kinetic analysis has provided a detailed quantitative description of the mechanism of actin polymerization as well as the methods to analyze the mechanisms of action of actin‐binding proteins. In Acanthamoeba, five different proteins regulate the pool of monomers available for polymerization, cap the end of filaments, sever filaments, and cross‐link filaments. Remarkably, many of these interactions involve very‐low‐affinity bonds between the protein molecules.