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Human restriction fragment length polymorphisms and cancer risk assessment
Author(s) -
Krontiris Theodore G.,
DiMartino Nancy A.,
Colb Mark,
Mitcheson H. David,
Parkinson David R.
Publication year - 1986
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240300405
Subject(s) - restriction fragment length polymorphism , fragment (logic) , genetics , biology , terminal restriction fragment length polymorphism , cancer , computational biology , cancer research , gene , genotype , computer science , algorithm
Abstract The polymorphic restriction fragments of the human Ha‐ ras locus, produced by the variable tandem repetition (VTR) of a short consensus sequence, fall into three classes based on allelic frequencies. Alleles of the “rare” class (individual frequencies < 0.5%) have been detected only in white blood cell and tumor DNA of cancer patients. This phenomenon is independent of ethnic origin. No significant association of rare alleles with cancer patients has been demonstrated at an independent tandem repeat locus, VTR4.1. The results suggest that the Ha‐ ras restriction fragment length polymorphism is useful in cancer risk assessment.