Premium
Antibodies specific for the carboxy‐terminal region of the major surface glycoprotein of simian rotavirus (SA11) and human rotavirus (Wa)
Author(s) -
Streckert HansJürgen,
Grunert Barbara,
Werchau Hermann
Publication year - 1986
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240300106
Subject(s) - rotavirus , simian , virology , capsid , antibody , biology , glycoprotein , gene , reoviridae , immunization , genome , virus , microbiology and biotechnology , biochemistry , genetics
Antibodies specific for the major outer capsid protein (VP7) of the simian rotavirus SA11 were obtained by immunization of rabbits with a synthetic peptide, Ser‐Ala‐Ala‐Phe‐Tyr‐Tyr‐Arg‐Val, corresponding to the eight carboxy‐terminal amino acids of the viral protein predicted from the nucleotide sequence of the gene segment 9 of the SA11 genome. As the carboxy‐terminal region of the VP7 of human rotavirus Wa has an identical sequence, cross‐reactivity of the raised antibodies was observed with this strain.