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A pathway of coagulation on endothelial cells
Author(s) -
Nawroth Peter P.,
Stern David M.
Publication year - 1985
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240280403
Subject(s) - tissue factor , endothelial stem cell , factor x , microbiology and biotechnology , thrombin , endothelium , coagulation , fibrinogen , fibrin , chemistry , cell , thromboplastin , tissue factor pathway inhibitor , factor vii , biology , immunology , biochemistry , platelet , medicine , endocrinology , in vitro
Although the endothelial cell is considered antithrombogenic, endothelium has recently been shown to participate in procoagulant reactions. Factor IX bound to specific endothelial cell sites can be activated by the intrinsic and extrinsic pathways of coagulation. Perturbation of endothelium results in induction of tissue factor which promotes factor VII a ‐mediated activation of factors IX and X. thus initiating procoagulant events on the endothelial surface. Cell bound factor IX a , in the presence of factor VIII, promotes activation of factor X. The factor X a formed can interact with endothelial cell factor V/V a , resulting in prothrombin activation. Thrombin then cleaves fibrinogen and a fibrin clot closely associated with the endothelial cell forms. The perturbed endothelial cell thus provides a focus of localized procoagulant events. This model suggests a simple endothelial‐cell‐dependent mechanism for initiation of coagulation at the site of an injured or pathological vessel.