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Interaction of epidermal growth factor with initiators and complete carcinogens in the C3H10T1/2 cell culture System
Author(s) -
Herschman Harvey R.,
Brankow David
Publication year - 1985
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240280102
Subject(s) - epidermal growth factor , carcinogen , chemistry , cell culture , microbiology and biotechnology , cell type , cell , biology , biochemistry , genetics
Unlike 12‐O‐tetradecanoylphorbol‐l3‐acctate, epidermal growth factor (EGF) could not promote the appearance of type III foci from initiated C3H10T1/2 cells. At appropriate concentrations, EGF induced the formation of type II colonies in the absence of any initiator. At higher concentrations, EGF suppressed the induction of both type II and type III colonies elicited by methylcholanthrene.