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Regulation of gonadotropin release, GnRH receptors, and gonadotrope responsiveness: A role for GnRH receptor microaggregation
Author(s) -
Conn P. Michael,
Rogers Deloris C.,
Seay Sallie G.,
Jinnah Hyder,
Bates Michael,
Luscher Diana
Publication year - 1985
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240270103
Subject(s) - gonadotropic cell , gonadotropin releasing hormone , receptor , luteinizing hormone , medicine , endocrinology , hormone receptor , gonadotropin releasing hormone receptor , follicle stimulating hormone , gonadotropin , hormone , thyrotropin releasing hormone receptor , anterior pituitary , chemistry , biology , cancer , breast cancer
Gonadotropin‐releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) release from pituitary gonadotrope cells. Additional receptor‐mediated actions of the releasing hormone include homologous regulation of both the GnRH receptor and of cell responsiveness. While it is apparent that the release mechanism is Ca 2+ mediated, it remains unclear how this receptor‐mediated action is integrated with regulation of the receptor and with cell responsiveness. It is the purpose of this review to describe the requirements for gonadotropin release as well as for receptor and response regulation in order to prepare an integrated model for these actions of the releasing hormone.