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The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation
Author(s) -
Ciechanover Aaron,
Finley Daniel,
Varshavsky Alexander
Publication year - 1984
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.240240104
Subject(s) - ubiquitin , intracellular , protein degradation , microbiology and biotechnology , histone , ubiquitins , chromatin , proteolysis , chemistry , biology , biochemistry , ubiquitin ligase , enzyme , gene
In this review we briefly describe the lysosomal system, consider the evidence for multiplicity of protein degradation pathways in vivo, discuss in detail the ubiquitin‐mediated pathway of intracellular ATP‐dependent protein degradation, and also the possible significance of ubiquitin‐histone conjugates in chromatin. For detailed discussions of the various characteristics and physiological roles of intracellular protein breakdown, the reader is referred to earlier reviews [1–7] and reports of recent symposia [8–10]. Information on the ubiquitin system prior to 1981 was described in an earlier review [11]. Hershko has briefly reviewed more recent information [12].