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Manipulation of cellular redox parameters for improving therapeutic responses in B‐cell lymphoma and multiple myeloma
Author(s) -
Goel Apollina,
Spitz Douglas R.,
Weiner George J.
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.23387
Subject(s) - cancer research , multiple myeloma , oxidative stress , apoptosis , lymphoma , cell , medicine , chemotherapy , radiation therapy , cancer cell , reactive oxygen species , cancer , biology , immunology , microbiology and biotechnology , biochemistry
Developing novel combined‐modality therapeutic approaches based on understanding of the involvement of redox biology in apoptosis of malignant cells is a promising approach for improving clinical responses in B‐cell lymphoma and multiple myeloma. Therapeutic modalities that generate reactive oxygen species (i.e., radiation, photodynamic therapy, and specific chemotherapeutic drugs) have been shown to be selectively cytotoxic to malignant B‐cells. In this review, we will discuss agents that induce apoptosis in B‐cell tumors by oxidative stress. Subsequently, a novel biochemical rationale (based on fundamental differences in cancer vs. normal cell oxidative metabolism) for combining oxidative stressors with radiotherapy and chemotherapy, that may lead to designing of more effective treatment strategies for B‐cell malignancies, will be discussed. Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug‐resistance in tumor cells, which is a major determinant of treatment failure in many B‐cell malignancies. J. Cell. Biochem. 113: 419–425, 2012. © 2011 Wiley Periodicals, Inc.