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Targeting AMPK in the treatment of malignancies
Author(s) -
Vakana Eliza,
Altman Jessica K.,
Platanias Leonidas C.
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.23369
Subject(s) - ampk , autophagy , pi3k/akt/mtor pathway , cancer research , microbiology and biotechnology , translation (biology) , malignant transformation , cell growth , cell , signal transduction , chemistry , protein kinase a , biology , apoptosis , phosphorylation , messenger rna , gene , biochemistry
The AMPK pathway is a metabolic stress‐related and energy censor pathway which plays important regulatory roles in normal and malignant cells. This cellular cascade controls generation of signals for initiation of mRNA translation via the mTOR pathway and exhibits regulatory roles on the initiation of autophagy. AMPK activators have been shown to suppress mTOR activity and to negatively control malignant transformation and cell proliferation of diverse malignant cell types. Such properties of AMPK inducers have generated substantial interest for the use of AMPK targeting compounds as antineoplastic agents and have provoked extensive research efforts to better define and classify the mechanisms controlling AMPK activity and its functional consequences in malignant cells. J. Cell. Biochem. 113: 404–409, 2012. © 2011 Wiley Periodicals, Inc.