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Regulation of anti‐apoptotic BCL2‐proteins by non‐canonical interactions: The next step forward or two steps back ?
Author(s) -
Beverly Levi J.
Publication year - 2012
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.23335
Subject(s) - apoptosis , microbiology and biotechnology , signal transduction , biology , non canonical , programmed cell death , computational biology , genetics
All aspects of cellular biology affect the process of regulated cell death, or apoptosis, and disruption of this process is a causative event in many diseases. Therefore, a comprehensive understanding of all pathways that regulate apoptosis would increase our knowledge of basic cellular functions, as well as the etiologies of many diseases. In turn, we may be able to use this knowledge to better treat patients with diseases, including cancer. Although the basic signaling pathway that regulates apoptosis has been known for over 10 years, we still have much to learn about the upstream signaling components that can directly regulate the core apoptosis machinery. The focus of this review will be to direct attention to non‐canonical regulators of the BCL2‐family of proteins, especially our void of understanding of such interactions, and the controversy that surrounds some such interactions. J. Cell. Biochem. 113: 3–12, 2012. © 2011 Wiley Periodicals, Inc.