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Complement regulator factor H in multiple sclerosis
Author(s) -
Ingram Gillian,
Hakobyan Svetlana,
Loveless Samantha,
Robertson Neil,
Morgan B. Paul
Publication year - 2011
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.23204
Subject(s) - regulator , multiple sclerosis , complement (music) , factor h , master regulator , complement system , microbiology and biotechnology , biology , immunology , transcription factor , genetics , antibody , phenotype , gene , complementation
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH in CSF, demonstrates no change in fH levels in active disease, but significantly raised levels in progressive disease. These findings support our previous work showing raised serum fH in patients with progressive MS, and our results predict that CSF fH levels will be raised rather than reduced in active disease. J. Cell. Biochem. 112: 2653–2654, 2011. © 2011 Wiley‐Liss, Inc.