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Signaling networks in RUNX2‐dependent bone development
Author(s) -
Komori Toshihisa
Publication year - 2011
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22994
Subject(s) - runx2 , osteoblast , chondrocyte , wnt signaling pathway , endochondral ossification , transcription factor , microbiology and biotechnology , fibroblast growth factor , biology , signal transduction , sox9 , cellular differentiation , anatomy , cartilage , genetics , receptor , gene , in vitro
RUNX2 is an essential transcription factor for osteoblast differentiation and chondrocyte maturation. SP7, another transcription factor, is required for osteoblast differentiation. Major signaling pathways, including FGF, Wnt, and IHH, also play important roles in skeletal development. RUNX2 regulates Sp7 expression at an early stage of osteoblast differentiation. FGF2 upregulates Runx2 expression and activates RUNX2, and gain‐of‐function mutations of FGFRs cause craniosynostosis and limb defect with upregulation of Runx2 expression. Wnt signaling upregulates Runx2 expression and activates RUNX2, and RUNX2 induces Tcf7 expression. IHH is required for Runx2 expression in osteoprogenitor cells during endochondral bone development, and RUNX2 directly regulates Ihh expression in chondrocytes. Thus, RUNX2 regulates osteoblast differentiation and chondrocyte maturation through the network with SP7 and with FGF, Wnt, and IHH signaling pathways during skeletal development. J. Cell. Biochem. 112: 750–755, 2011. © 2010 Wiley‐Liss, Inc.