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Loss of runt‐related transcription factor 3 causes development and progression of hepatocellular carcinoma
Author(s) -
Shiraha Hidenori,
Nishina Shinichi,
Yamamoto Kazuhide
Publication year - 2011
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22973
Subject(s) - hepatocellular carcinoma , cancer research , transcription factor , suppressor , angiogenesis , tumor suppressor gene , biology , dna methylation , cell cycle , cancer , gene , medicine , gene expression , carcinogenesis , genetics
Runt‐related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial–mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC. J. Cell. Biochem. 112: 745–749, 2011. © 2010 Wiley‐Liss, Inc.