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Functions of Runx in IgA class switch recombination
Author(s) -
Sugai Manabu,
Watanabe Kakeru,
Nambu Yukiko,
Hayashi Tatsunari,
Shimizu Akira
Publication year - 2011
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22971
Subject(s) - transcription factor , microbiology and biotechnology , biology , haematopoiesis , immune system , cell , recombination , genetics , immunology , gene , stem cell
Runt ‐related ( Runx ) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoietic and skeletal disorders. Recently, extensive investigations have revealed new functions of these transcription factors in immune cell differentiation and functioning. In the present review, we discuss the mechanisms of selective IgA production in the intestine and report the involvement of Runx proteins in this process. J. Cell. Biochem. 112: 409–414, 2011. © 2010 Wiley‐Liss, Inc.