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New insights into the inactivation of gastric tumor suppressor RUNX3: The role of H. pylori infection
Author(s) -
Tsang YingHung Nicole,
Lamb Acacia,
Chen LinFeng
Publication year - 2011
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22964
Subject(s) - suppressor , helicobacter pylori , cancer , pathogenesis , cancer research , transcription factor , biology , immunology , medicine , gene , genetics
Runt‐related transcription factor 3, or RUNX3, is a tumor suppressor in gastric cancer. Inactivation of RUNX3 is causally associated with the genesis of gastric cancer, since RUNX3 is frequently inactivated in gastric cancers by hemizygous deletion, hypermethylation of its promoter, or protein mislocalization. Infection with Helicobacter pylori is the strongest risk factor for the development of gastric cancer. Recent studies have indicated that H. pylori infection plays an important role in the inactivation of RUNX3, and that this inactivation contributes to the pathogenesis of H. pylori . Here we summarize these recent advances and discuss their significances in understanding the initiation and development of gastric cancer. J. Cell. Biochem. 112: 381–386, 2011. © 2010 Wiley‐Liss, Inc.