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Antagonistic interplay between mechanical forces and glucocorticoids in bone: A tale of kinases
Author(s) -
Bellido Teresita
Publication year - 2010
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22660
Subject(s) - osteocyte , microbiology and biotechnology , focal adhesion , mechanotransduction , kinase , integrin , extracellular matrix , wnt signaling pathway , signal transduction , osteoblast , chemistry , biology , cell , biochemistry , in vitro
The contrasting actions of mechanical forces and glucocorticoids (GC) on bone have been long recognized. However, the cellular and molecular mechanisms by which these stimuli impact the skeleton remain only partially known. Recent evidence gained from studies on bone cell apoptosis has revealed that mechanical forces and GC exhibit converse effects on osteocyte and osteoblast survival resulting from divergent actions on the focal adhesion kinases FAK and Pyk2, molecules that regulate integrin‐dependent interactions between bone cells and the extracellular matrix (ECM). This prospect reviews these findings and poses the possibility that similar opposing effects on kinase signaling are responsible for other actions of mechanical forces and GC on the skeleton, in particular on bone formation and the Wnt signaling pathway. J. Cell. Biochem. 111: 1–6, 2010. © 2010 Wiley‐Liss, Inc.