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Pathology and biology associated with the fragile FHIT gene and gene product
Author(s) -
Saldivar Joshua C.,
Shibata Hidetaka,
Huebner Kay
Publication year - 2010
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22481
Subject(s) - fhit , chromosomal fragile site , locus (genetics) , epigenetics , biology , gene , genetics , allele , gene expression , gene product , loss of heterozygosity , chromosome , cancer research , tumor suppressor gene , carcinogenesis
More than 12 years and >800 scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B , there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression of FHIT , the most frequent target of allele deletion in precancerous lesions and cancers. These questions are considered in light of recent investigations of genetic and epigenetic alterations to the locus and in a retrospective consideration of biological roles of the Fhit protein discovered through functional studies. J. Cell. Biochem. 109: 858–865, 2010. © 2010 Wiley‐Liss, Inc.