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Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA‐1, and P‐TEFb
Author(s) -
Goldfarb Adam N.
Publication year - 2009
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22142
Subject(s) - runx1 , biology , transcription factor , transcriptional regulation , microbiology and biotechnology , p tefb , transcription (linguistics) , regulator , megakaryocytopoiesis , megakaryocyte , progenitor cell , genetics , stem cell , gene , gene expression , promoter , linguistics , philosophy
Transcription factors originally identified as drivers of erythroid differentiation subsequently became linked to megakaryopoiesis, reflecting the shared parentage of red cells and platelets. The divergent development of megakaryocytic and erythroid progenitors relies on signaling pathways that impose lineage‐specific transcriptional programs on non‐lineage‐restricted protein complexes. One such signaling pathway involves RUNX1, a transcription factor upregulated in megakaryocytes and downregulated in erythroid cells. In this pathway, RUNX1 engages the erythro‐megakaryocytic master regulator GATA‐1 in a megakaryocytic transcriptional complex whose activity is highly dependent on the P‐TEFb kinase complex. The implications of this pathway for normal and pathological megakaryopoiesis are discussed. J. Cell. Biochem. 107: 377–382, 2009. © 2009 Wiley‐Liss, Inc.