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Location, location, (ChIP‐)location! Mapping chromatin landscapes one immunoprecipitation at a time
Author(s) -
Berman Benjamin P.,
Frenkel Baruch,
Coetzee Gerhard A.
Publication year - 2009
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22133
Subject(s) - chromatin immunoprecipitation , computational biology , genome , genomics , chromatin , biology , context (archaeology) , tiling array , chip sequencing , gene , computer science , data science , evolutionary biology , genetics , dna microarray , chromatin remodeling , gene expression , promoter , paleontology
A small fraction of the typical animal genome (<5% in humans) codes for the organism's collection of proteins, yet the study of protein coding sequences dominated the early years of genomics research. In the decade since the sequencing of complete eukaryotic genomes, however, genomic techniques have shed a great deal of light on the non‐coding DNA making up the remainder. A single molecular technique, Chromatin Immuno‐Precipitation (ChIP) location analysis, has had a profound impact and has made possible the study of an incredible range of biology. This issue of The Journal of Cellular Biochemistry aims to put into context advancements made possible by the ChIP‐location revolution, while at the same time highlighting some of the most important technical aspects and challenges along with some of the work yet to come. J. Cell. Biochem. 107: 1–5, 2009. © 2009 Wiley‐Liss, Inc.