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From sextant to GPS: Twenty‐five years of mapping the genome with ChIP
Author(s) -
Wacker David A.,
Kim Tae Hoon
Publication year - 2009
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.22060
Subject(s) - milestone , chip , honor , genome , scale (ratio) , global positioning system , computational biology , computer science , biology , geography , genetics , archaeology , gene , cartography , telecommunications , operating system
Since its inception, ChIP technology has evolved immensely. Technological advances have improved its specificity and sensitivity, its scale has expanded to a genome‐wide level, and its relative ease of use has made it a virtually ubiquitous tool. This year marks the 25th anniversary of the development of ChIP. In honor of this milestone, we briefly revisit its history, offer a review of recent articles employing ChIP on a genome‐wide scale, and lay out our views for the future of ChIP. J. Cell. Biochem. 107: 6–10, 2009. © 2009 Wiley‐Liss, Inc.
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