Premium
Aging and lung injury repair: A role for bone marrow derived mesenchymal stem cells
Author(s) -
Mora Ana L.,
Rojas Mauricio
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21890
Subject(s) - mesenchymal stem cell , bone marrow , extracellular matrix , progenitor cell , senescence , lung , fibrosis , stem cell , medicine , pulmonary fibrosis , extracellular , cancer research , pathology , microbiology and biotechnology , biology
The incidence of lung fibrosis increases with age. Aging is associated with modifications in the intracellular and extracellular environment including alteration of the extracellular matrix, imbalance of the redox state, accumulation of senescent cells and potential alteration of the recruitment of bone marrow mesenchymal stem cells. The combination of these senescence‐related alterations in the lung and in bone marrow progenitor cells might be responsible of the higher susceptibility to lung fibrosis in elderly individuals. The understanding of these age related changes must be considered in the rationale for the development of therapeutic interventions to control lung injury and fibrosis. J. Cell. Biochem. 105: 641–647, 2008. © 2008 Wiley‐Liss, Inc.