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Nuclear microenvironments and cancer
Author(s) -
Stein Gary S.,
Davie James R.,
Knowlton J. Randy,
Zaidi Sayyed K.
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21846
Subject(s) - biology , computational biology , carcinogenesis , cancer , proteomics , compartmentalization (fire protection) , genomics , functional genomics , gene , microbiology and biotechnology , genetics , genome , biochemistry , enzyme
Nucleic acids and regulatory proteins are architecturally organized in nuclear microenvironments. The compartmentalization of regulatory machinery for gene expression, replication and repair, is obligatory for fidelity of biological control. Perturbations in the organization, assembly and integration of regulatory machinery have been functionally linked to the onset and progression of tumorigenesis. The combined application of cellular, molecular, biochemical and in vivo genetic approaches, together with structural biology, genomics, proteomics and bioinformatics, will likely lead to new approaches in cancer diagnostics and therapy. J. Cell. Biochem. 104: 1949–1952, 2008. © 2008 Wiley‐Liss, Inc.