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Pregabalin and gabapentin inhibit substance P‐induced NF‐κB activation in neuroblastoma and glioma cells
Author(s) -
Park Seyeon,
Ahn Eun Sook,
Han Dong Woo,
Lee Jong Hwa,
Min Kyung Tae,
Kim Hyunkyung,
Hong YongWoo
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21837
Subject(s) - pregabalin , gabapentin , pharmacology , chemistry , neuropathic pain , neuroblastoma , glioma , nf κb , analgesic , intracellular , substance p , medicine , cancer research , receptor , biochemistry , cell culture , neuropeptide , biology , signal transduction , anesthesia , pathology , alternative medicine , genetics
Pregabalin and gabapentin are lipophilic amino acid derivatives of γ‐amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P‐induced NF‐κB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P‐induced NF‐κB activation in these cells. These drugs also inhibited NF‐κB activation in rat spinal dorsal root ganglia cells pre‐treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation‐related intracellular signaling in both neuronal and glial cells. J. Cell. Biochem. 105: 414–423, 2008. © 2008 Wiley‐Liss, Inc.