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Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
Author(s) -
Stein Gary S.,
Zaidi Sayyed K.,
Stein Janet L.,
Lian Jane B.,
van Wijnen Andre J.,
Montecino Martin,
Young Daniel W.,
Javed Amjad,
Pratap Jitesh,
Choi JeYong,
Ali Syed A.,
Pande Sandhya,
Hassan Mohammad Q.
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21813
Subject(s) - epigenetics , carcinogenesis , biology , regulation of gene expression , cancer , computational biology , epigenesis , gene , gene expression , genetics , microbiology and biotechnology , bioinformatics , dna methylation
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment. J. Cell. Biochem. 104: 2016–2026, 2008. © 2008 Wiley‐Liss, Inc.