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Centromeres in cell division, evolution, nuclear organization and disease
Author(s) -
Gonçalves dos Santos Silva Amanda,
Sarkar Rahul,
Harizanova Jana,
Guffei Amanda,
Mowat Michael,
Garini Yuval,
Mai Sabine
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21766
Subject(s) - centromere , biology , cell division , disease , chromosome , microbiology and biotechnology , division (mathematics) , chromosome segregation , cell , function (biology) , multidisciplinary approach , computational biology , genetics , evolutionary biology , political science , medicine , gene , pathology , arithmetic , mathematics , law
As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three‐dimensional organization of centromeres in normal and tumor cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division. J. Cell. Biochem. 104: 2040–2058, 2008. © 2008 Wiley‐Liss, Inc.