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Coactivators and nuclear receptor transactivation
Author(s) -
Wolf Irene M.,
Heitzer Marjet D.,
Grubisha Melanie,
DeFranco Donald B.
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21755
Subject(s) - nuclear receptor , pelp 1 , chromatin , transactivation , nuclear receptor coactivator 1 , microbiology and biotechnology , histone , biology , chromatin remodeling , transcription factor , rna splicing , transcription coregulator , nuclear protein , alternative splicing , genetics , messenger rna , gene , rna
A variety of coregulator proteins serve as partners for nuclear receptors orchestrating the molecular events required for receptor‐dependent transcriptional regulation. Some coregulators directly interact with nuclear receptors and provide a platform for recruitment of other factors that provide distinct biochemical activities that influence transcriptional efficiency. Coregulators can influence chromatin structure and activity via direct modification of histone proteins or by facilitating ATP‐dependent chromatin remodeling. They also have the capacity to impact multiple steps in the transcription process including initiation, elongation, and mRNA splicing. Genetic analysis in humans and animal models are revealing the important cell and tissue‐type specific actions of nuclear receptor coregulators as well and their role in human physiology and disease. J. Cell. Biochem. 104: 1580–1586, 2008. © 2008 Wiley‐Liss, Inc.