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Where shall we meet? A role for genome organisation and nuclear sub‐compartments in mediating interchromosomal interactions
Author(s) -
Osborne Cameron S.,
Eskiw Christopher H.
Publication year - 2008
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21750
Subject(s) - biology , genome , genetics , context (archaeology) , gene , relation (database) , computational biology , computer science , paleontology , database
A recent spate of examples of specific interactions between loci on separate chromosomes in mammalian nuclei has illuminated another layer of complexity in gene regulation. As the specifics of the cross‐talk between interacting loci are worked out, it is also important to consider exactly how, when and where loci can ever reliably find each other within such an intricate environment. Answers may lie in how the genome is organised in relation to itself and to specialised nuclear sub‐compartments. Here, we discuss how such specialised nuclear bodies may have the potential to specifically sequester loci and provide a context where interchromosomal communications can occur. J. Cell. Biochem. 104: 1553–1561, 2008. © 2008 Wiley‐Liss, Inc.