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Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP‐9 activity through AKT signaling pathway
Author(s) -
Jin UnHo,
Suh SeokJong,
Chang Hyen Wook,
Son JongKeun,
Lee Seung Ho,
Son KunHo,
Chang YoungChae,
Kim CheorlHo
Publication year - 2007
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21599
Subject(s) - salvia miltiorrhiza , phosphorylation , vascular smooth muscle , protein kinase b , chemistry , cell migration , p38 mitogen activated protein kinases , pharmacology , restenosis , mapk/erk pathway , matrix metalloproteinase , cell , microbiology and biotechnology , smooth muscle , medicine , biology , biochemistry , pathology , alternative medicine , traditional chinese medicine , stent
Smooth muscle cell (SMC) migration plays an important role in normal angiogenesis and is relevant to disease‐related vascular remodeling in conditions such as brain arteriovenous malformations, pulmonary hypertension, arteriosclerosis, and restenosis after angioplasty. In this present study, we showed that tanshinone IIA, the major lipid‐soluble pharmacological constituent of Salvia miltiorrhiza BUNGE, inhibits human aortic smooth muscle cell (HASMC) migration and MMP‐9 activity. Tanshinone IIA significantly inhibited IκBα phosphorylation and p65 nuclear translocation through inhibition of AKT phosphorylation. Tanshinone IIA inhibited TNF‐α‐induced ERK and c‐jun phosphorylation, but not other MAPKs such as JNK and p38. Tanshinone IIA also inhibited NF‐κB and AP‐1 DNA‐binding. Moreover, tanshinone IIA inhibited the migration of TNF‐α‐induced HASMCs. Our results provide evidence that tanshinone IIA has multiple effects in the inhibition of HASMC migration and may offer a therapeutic approach to block HASMC migration. J. Cell. Biochem. 104: 15–26, 2008. © 2007 Wiley‐Liss, Inc.