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Nuclear architecture: Is it important for genome function and can we prove it?
Author(s) -
MateosLangerak Julio,
Goetze Sandra,
Leonhardt Heinrich,
Cremer Thomas,
van Driel Roel,
Lanctôt Christian
Publication year - 2007
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21521
Subject(s) - chromatin , enhancer , genome , biology , gene , chia pet , computational biology , scaffold/matrix attachment region , genetics , function (biology) , genomic organization , promoter , gene expression , chromatin remodeling
Gene regulation in higher eukaryotes has been shown to involve regulatory sites, such as promoters and enhancers which act at the level of individual genes, and mechanisms which control the functional state of gene clusters. A fundamental question is whether additional levels of genome control exist. Nuclear organization and large‐scale chromatin structure may constitute such a level and play an important role in the cell‐type specific orchestration of the expression of thousands of genes in eukaryotic cells. Numerous observations indicate a tight correlation between genome activity and nuclear and large‐scale chromatin structure. However, causal relationships are rare. Here we explore how these might be uncovered. J. Cell. Biochem. 102: 1067–1075, 2007. © 2007 Wiley‐Liss, Inc.