Premium
Age‐related gene expression profiles of rhesus monkey bone marrow‐derived mesenchymal stem cells
Author(s) -
Hacia Joseph G.,
Lee C. Chang I.,
Jimenez Daniel F.,
Karaman Mazen W.,
Ho Vincent V.,
Siegmund Kimberley D.,
Tarantal Alice F.
Publication year - 2007
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21498
Subject(s) - mesenchymal stem cell , gene expression , biology , stem cell , progenitor cell , gene , bone marrow , fetus , andrology , immunology , microbiology and biotechnology , genetics , medicine , pregnancy
The objective of this study was to elucidate age‐related differences in gene expression profiles of rhesus monkey bone marrow‐derived mesenchymal stem cells (rhMSC) obtained from fetal, infant, and adult donors relevant to their growth and other properties. Although a high degree of similarity was observed in the rhMSC gene expression profiles when comparing the three age groups, significant differences were found that strongly parallel gene expression profiles of human MSC. In general, there was a trend towards increased abundance of transcripts associated with differentiation and growth arrest with increasing donor age. Conversely, transcripts involved in RNA processing and the negative regulation of gene expression showed a downward trend with increasing donor age. Overall, the observed gene expression profiles were found to be similar to observations that MSC from older individuals show diminished proliferative capacity. These data highlight the importance of use of non‐human primates to study the properties of stem and progenitor cells, and for future therapies. J. Cell. Biochem. 103: 1198–1210, 2008. © 2007 Wiley‐Liss, Inc.