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Cytoskeletal elements and intracellular transport
Author(s) -
Bhaskar Lakshmi,
Krishnan Vidya S.,
Thampan Raghava Varman
Publication year - 2007
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21347
Subject(s) - cytoskeleton , intracellular , microtubule , microbiology and biotechnology , intracellular transport , actin , molecular motor , motor protein , receptor , biology , chemistry , cell , biochemistry
Recent advances in the understanding of the functions of various components of the cytoskeleton indicate that, besides serving a structural role, the cytoskeletal elements may regulate the transport of several proteins in the cell. Studies reveal that there are co‐operative interactions between the actin and microtubule cytoskeletons including functional overlap in the transport influenced by different motor families. Multiple motors are probably involved in the control of the dynamics of many proteins and intriguing hints about how these motors are co‐ordinated are appearing. It has been shown that some of the intermediate elements also participate in selected intracellular transport mechanisms. In view of the author's preoccupation with the steroid receptor systems, special attention has been given to the role of the cytoskeletal elements, particularly actin, in the intracellular transport of steroid receptors and receptor‐related proteins. J. Cell. Biochem. 101:1097–1108, 2007. © 2007 Wiley‐Liss, Inc.