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Long‐term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats
Author(s) -
Westbroek I.,
Waarsing J.H.,
van Leeuwen J.P.T.M.,
Waldum H.,
Reseland J.E.,
Weinans H.,
Syversen U.,
Gustafsson B.I.
Publication year - 2006
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.21177
Subject(s) - fluoxetine , leptin , endocrinology , adiponectin , serotonergic , medicine , bone remodeling , serotonin , bone mineral , chemistry , osteoporosis , diabetes mellitus , obesity , insulin resistance , receptor
Many studies have indicated that serotonin and its transporter play a role in bone metabolism. In this study we investigated the effect of selective serotonin re‐uptake inhibitor (SSRI), fluoxetine (Prozac ® ) on bone architecture and quality in growing female rats. We therefore administrated rats with clinically relevant doses of fluoxetine for a period of 6 months. DXA scans were performed during the treatment period in order to follow parameters as body weight, fat percentage and BMD. After 6 months of treatment, femurs were used to analyze bone architecture and bone strength, by means of µCT scans and three‐point bending assays, respectively. We found a slightly diminished bone quality, reflected in a lower bone tissue strength, which was compensated by changes in bone geometry. As leptin and adiponectin could be possible factors in the serotonergic regulation of bone metabolism, we also determined the levels of these factors in plasma samples of all animals. Leptin and adiponectin levels were not different between the control group and fluoxetine‐treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality. J. Cell. Biochem. 101: 360–368, 2007. © 2006 Wiley‐Liss, Inc.

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